Bawden EG, Wagner T, Schröder J, Effern M, Hinze D, Newland L, Attrill GH, Lee AR, Engel S, Freestone D, De Lima Moreira M, Gressier E, McBain N, Bachem A, Haque A, Dong R, Ferguson AL, Edwards JJ, Ferguson PM, Scolyer RA, Wilmott JS, Jewell CM, Brooks AG, Gyorki DE, Palendira U, Bedoui S, Waithman J, Hochheiser K, Hölzel M, Gebhardt T. CD4 + T Cell Immunity against Cutaneous Melanoma Encompasses Multifaceted MHC II–Dependent Responses. Sci. Immunol. 2024, 9 (91), eadi9517. https://doi.org/10.1126/sciimmunol.adi9517.
Chang Y, Bach L, Hasiuk M, Wen L, Elmzzahi T, Tsui C, Gutiérrez-Melo N, Steffen T, Utzschneider DT, Raj T, Jost PJ, Heink S, Cheng J, Burton OT, Zeiträg J, Alterauge D, Dahlström F, Becker JC, Kastl M, Symeonidis K, van Uelft M, Becker M, Reschke S, Krebs S, Blum H, Abdullah Z, Paeschke K, Ohnmacht C, Neumann C, Liston A, Meissner F, Korn T, Hasenauer J, Heissmeyer V, Beyer M, Kallies A, Jeker LT, Baumjohann D. TGF-β specifies TFH versus TH17 cell fates in murine CD4+ T cells through c-Maf. Sci Immunol. 2024 Mar;9(93):eadd4818. doi: 10.1126/sciimmunol.add4818. Epub 2024 Mar 1. PMID: 38427718.
Gnirck AC, Philipp MS, Waterhölter A, Wunderlich M, Shaikh N, Adamiak V, Henneken L, Kautz T, Xiong T, Klaus D, Tomczyk P, Al-Bahra MM, Menche D, Walkenhorst M, Lantz O, Willing A, Friese MA, Huber TB, Krebs CF, Panzer U, Kurts C, Turner JE. Mucosal-Associated Invariant T Cells Contribute to Suppression of Inflammatory Myeloid Cells in Immune-Mediated Kidney Disease. Nat. Commun. 2023, 14 (1), 7372. https://doi.org/10.1038/s41467-023-43269-0.
Mohamed AA, Soler S, Wegner J, Bartok E, Stankovic S, Brooks AG, Schlee M. Influenza A Infection Stimulates RIG-I and Enhances Effector Function of Primary Human NK Cells. Int. J. Mol. Sci. 2023, 24 (15), 12220. https://doi.org/10.3390/ijms241512220.
Bonaguro L, Schulte-Schrepping J, Carraro C, Sun LL, Reiz B, Gemünd I, Saglam A, Rahmouni S, Georges M, Arts P, Hoischen A, Joosten LAB, van de Veerdonk FL, Netea MG, Händler K, Mukherjee S, Ulas T, Schultze JL, Aschenbrenner AC. Human Variation in Population-Wide Gene Expression Data Predicts Gene Perturbation Phenotype. iScience 2022, 105328. https://doi.org/10.1016/j.isci.2022.105328.
Jenster LM, Lange KE, Normann S, vom Hemdt A, Wuerth JD, Schiffelers LDJ, Tesfamariam YM, Gohr FN, Klein L, Kaltheuner IH, Ebner S, Lapp DJ, Mayer J, Moecking J, Ploegh HL, Latz E, Meissner F, Geyer M, Kümmerer BM, Schmidt FI. P38 Kinases Mediate NLRP1 Inflammasome Activation after Ribotoxic Stress Response and Virus Infection. J. Exp. Med. 2023, 220 (1), e20220837.
Georg P, Astaburuaga-García R, Bonaguro L, Brumhard S, Michalick L, Lippert LJ, Kostevc T, Gäbel C, Schneider M, Streitz M, Demichev V, Gemünd I, Barone M, Tober-Lau P, Helbig ET, Hillus D, Petrov L, Stein J, Dey HP, Paclik D, Iwert C, Mülleder M, Aulakh SK, Djudjaj S, Bülow RD, Mei HE, Schulz AR, Thiel A, Hippenstiel S, Saliba AE, Eils R, Lehmann I, Mall MA, Stricker S, Röhmel J, Corman VM, Beule D, Wyler E, Landthaler M, Obermayer B, von Stillfried S, Boor P, Demir M, Wesselmann H, Suttorp N, Uhrig A, Müller-Redetzky H, Nattermann J, Kuebler WM, Meisel C, Ralser M, Schultze JL, Aschenbrenner AC, Thibeault C, Kurth F, Sander LE, Blüthgen N, Sawitzki B. Complement Activation Induces Excessive T Cell Cytotoxicity in Severe COVID-19. Cell 2021, S0092867421015622. https://doi.org/10.1016/j.cell.2021.12.040.
Koenig PA, Das H, Liu H, Kümmerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Tödtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hällberg BM, Wu NC, Schmidt FI. Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape. Science 12.Januar 2021;eabe6230.
Assmus LM, Guan J, Wu T, Farenc C, Sng XYX, Zareie P, Nguyen A, Nguyen AT, Tscharke DC, Thomas PG, Rossjohn J, Gras S, Croft NP, Purcell AW, La Gruta NL. Overlapping Peptides Elicit Distinct CD8 + T Cell Responses following Influenza A Virus Infection. J. Immunol. 205, 1731–1742 (2020).
Quinn KM, Hussain T, Kraus F, Formosa LE, Lam WK, Dagley MJ, Saunders EC, Assmus LM, Wynne-Jones E, Loh L, van de Sandt CE, Cooper L, Good-Jacobson KL, Kedzierska K, Mackay LK, McConville MJ, Ramm G, Ryan MT, La Gruta NL. Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality. Nat. Commun. 11, 2857 (2020).
Anderson BM, Poole DP, Aurelio L, Ng GZ, Fleischmann M, Kasperkiewicz P, Morissette C, Drag M, van Driel IR, Schmidt BL, Vanner SJ, Bunnett NW, Edgington-Mitchell LE. Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease. Sci. Rep. 2019;9(1):13295.
Bachem A, Makhlouf C, Binger KJ, de Souza DP, Tull D, Hochheiser K, Whitney PG, Fernandez-Ruiz D, Dahling S, Kastenmuller W, Jonsson J, Gressier E, Lew AM, Perdomo C, Kupz A, Figgett W, Mackay F, Oleshansky M, Russ BE, Parish IA, Kallies A, McConville MJ, Turner SJ, Gebhardt T, and Bedoui S. Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8(+) T Cells. Immunity. 2019.
Christ A*, Günther P*, Lauterbach MAR, Duewell P, Biswas D, Pelka K, Scholz CJ, Oosting M, Haendler K, Bassler K, Klee K, Schulte-Schrepping J, Ulas T, Moorlag S, Kumar V, Park MH, Joosten LAB, Groh LA, Riksen NP, Espevik T, Schlitzer A, Li Y, Fitzgerald ML, Netea MG, Schultze JL, and Latz E. Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming. Cell. 2018;172(1-2):162-75 e14.
Davidson S, Steiner A, Harapas CR, and Masters SL. An Update on Autoinflammatory Diseases: Interferonopathies. Current rheumatology reports. 2018;20(7):38.
Ardura-Fabregat A, Boddeke E, Boza-Serrano A, Brioschi S, Castro-Gomez S, Ceyzeriat K, Dansokho C, Dierkes T, Gelders G, Heneka MT, Hoeijmakers L, Hoffmann A, Laccarino L, Jahnert S, Kuhbandner K, Landreth G, Lonnemann N, Loschmann PA, McManus RM, Paulus A, Reemst K, Sanchez-Caro JM, Tiberi A, Van der Perren A, Vautheny A, Venegas C, Webers A, Weydt P, Wijasa TS, Xiang X, and Yang Y. Targeting Neuroinflammation to Treat Alzheimer's Disease. CNS drugs. 2017;31(12):1057-82.
Brewitz A*, Eickhoff S*, Dahling S, Quast T, Bedoui S, Kroczek RA, Kurts C, Garbi N, Barchet W, Iannacone M, Klauschen F, Kolanus W, Kaisho T, Colonna M, Germain RN, and Kastenmuller W. CD8(+) T Cells Orchestrate pDC-XCR1(+) Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming. Immunity. 2017;46(2):205-19.
Hoss F, Budden CF, and Latz E. IRGB10 Exposes Bacteria's Intimate Secrets. Developmental cell. 2016;39(1):7-8.
Mass E*, Ballesteros I*, Farlik M*, Halbritter F*, Günther P*, Crozet L, Jacome-Galarza CE, Handler K, Klughammer J, Kobayashi Y, Gomez-Perdiguero E, Schultze JL, Beyer M, Bock C, and Geissmann F. Specification of tissue-resident macrophages during organogenesis. Science. 2016;353(6304).
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"FVIII-albumin fusion proteins enhance the induction of immune tolerance towards coagulation factor VIII in haemophilia A mice"
"Modelling mechanisms of resistance to T cell-based therapy of solid cancers"
"Nucleic acid sensing in CD8 T cells and NK cells during viral infections"
"Antiviral and antimicrobial inflammasome formation in intestinal epithelial cells"
"Characterisation of Inflammasome-Induced Extracellular Vesicles, Their Uptake by and Effect on Bystander Cells"
"Inflammation-dependent differentiation of two distinct regulatory T cell populations in the visceral adipose tissue shapes systemic metabolism"
"From pattern recognition to pro-inflammatory cell death - Functional characterization of the proteins NLRP7 and GSDMD"
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"Development of a CRISPR/Cas9 based RiboTag strategy to identify regulators of melanoma immune interaction"
"Global 3'-UTR Length Changes Form a Novel Layer of Regulation in the Macrophage Response to Interferon-Beta"
"Role of IFN-y induced genes in cell autonomous defence against Legionellae"
“Nucleic acid sensing in CD4 T cells during HIV-1 and other viral infections”
„Impact of chronic liver inflammation on adaptive immune responses to viral infection”
„Characterisation of Extracellular Vesicles Released upon NLRP3 Activation and Their Impact on Bystander Cells"
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